Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AFE_0403Conserved hypothetical protein; Identified by similarity to GB:AAN48171.1. (105 aa)    
Predicted Functional Partners:
AFE_0530
Carbohydrate kinase, PfkB family; Identified by match to protein family HMM PF00294.
  
  
  0.921
pyrR
PyrR bifunctional protein; Identified by similarity to SP:P39765; match to protein family HMM PF00156.
     
 0.912
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Adenosine deaminase; Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism.
     
 0.902
AFE_0364
Hypoxanthine-guanine phosphoribosyltransferase, putative; Identified by similarity to SP:P37472; match to protein family HMM PF00156.
     
  0.900
AFE_0432
Conserved hypothetical protein TIGR00726; Identified by similarity to GB:AAQ59864.1; match to protein family HMM PF02578; match to protein family HMM TIGR00726; Belongs to the multicopper oxidase YfiH/RL5 family.
     
  0.900
surE
Acid phosphatase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
     
  0.900
AFE_0540
Adenine phosphoribosyltransferase, putative; Identified by similarity to SP:Q59049; match to protein family HMM PF00156.
     
  0.900
AFE_0772
Guanine deaminase, putative; Identified by similarity to SP:P76641; match to protein family HMM PF01979.
     
  0.900
AFE_0808
Oxidoreductase, FAD-binding subunit; Identified by similarity to SP:P77324; match to protein family HMM PF00941; match to protein family HMM PF03450.
     
  0.900
AFE_0809
Oxidoreductase, molybdopterin binding subunit; Identified by match to protein family HMM PF01315; match to protein family HMM PF02738.
     
  0.900
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
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