Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AFE_0447Sigma-54 dependent DNA-binding response regulator; Identified by match to protein family HMM PF00072; match to protein family HMM PF00158; match to protein family HMM PF07728. (461 aa)    
Predicted Functional Partners:
AFE_0449
Sensor histidine kinase; Identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518.
 
 
  0.984
rpoN
RNA polymerase sigma-54 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
 
  
 0.953
AFE_2957
Sensor histidine kinase; Identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518.
  
 
  0.933
AFE_2955
Sigma-54 dependent DNA-binding response regulator, putative; Identified by match to protein family HMM PF00072; match to protein family HMM PF00158.
  
  
 
0.906
AFE_0448
Lipoprotein, putative.
       0.805
ntrB
Nitrogen regulation protein NR(II); Identified by similarity to SP:P06218; match to protein family HMM PF00512; match to protein family HMM PF02518; match to protein family HMM PF08448.
 
 0.632
AFE_0184
Sensor protein PilS, putative; Identified by similarity to SP:P33639; match to protein family HMM PF00512; match to protein family HMM PF02518.
 
 
 0.590
AFE_0026
Sensor histidine kinase; Identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518.
 
 
 0.583
AFE_0446
Conserved hypothetical protein; Identified by similarity to GB:AAO91056.1.
       0.570
AFE_1595
Hypothetical protein; Identified by glimmer; putative.
  
 
 0.492
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
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