Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AFE_0485MotA/TolQ/ExbB proton channel family protein; Identified by match to protein family HMM PF01618. (206 aa)    
Predicted Functional Partners:
AFE_0486
Biopolymer transport protein, ExbD/TolR family; Identified by match to protein family HMM PF02472.
 
   0.975
AFE_3004
Biopolymer transport protein, ExbD/TolR family; Identified by match to protein family HMM PF02472.
 
   0.817
AFE_0769
Biopolymer transport protein, ExbD/TolR family; Identified by match to protein family HMM PF02472.
 
   0.795
AFE_2269
Biopolymer transport protein, ExbD/TolR family; Identified by match to protein family HMM PF02472.
 
   0.733
AFE_3026
ABC transporter, ATP-binding protein; Identified by match to protein family HMM PF00005.
  
     0.722
AFE_1486
Biopolymer transport protein, ExbD/TolR family; Identified by match to protein family HMM PF02472.
  
   0.705
AFE_2300
Biopolymer transport protein, ExbD/TolR family; Identified by match to protein family HMM PF02472.
 
   0.690
lpxK
Tetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
 
     0.659
tolR
TolR protein; Identified by similarity to SP:P05829; match to protein family HMM PF02472; match to protein family HMM TIGR02801.
 
   0.641
kdsB
3-deoxy-D-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
 
     0.630
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
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