Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AFE_0490Conserved hypothetical protein; Identified by similarity to GB:CAD16238.1; match to protein family HMM PF03966; Belongs to the UPF0434 family. (60 aa)    
Predicted Functional Partners:
kdsB
3-deoxy-D-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
  
  
 0.861
lpxK
Tetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
       0.799
AFE_0487
Conserved hypothetical protein; Identified by similarity to PIR:F64553; match to protein family HMM PF04028.
       0.794
AFE_0488
Hypothetical protein; Identified by glimmer; putative.
       0.784
ppa
Inorganic pyrophosphatase; Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
       0.705
AFE_0485
MotA/TolQ/ExbB proton channel family protein; Identified by match to protein family HMM PF01618.
       0.534
AFE_0486
Biopolymer transport protein, ExbD/TolR family; Identified by match to protein family HMM PF02472.
       0.534
AFE_0493
Hypothetical protein; Identified by glimmer; putative.
       0.534
AFE_0484
DNA internalization-related competence protein ComEC/Rec2; Identified by match to protein family HMM PF03772; match to protein family HMM TIGR00360.
       0.448
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
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