Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Neighborhood
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
AFE_0530Carbohydrate kinase, PfkB family; Identified by match to protein family HMM PF00294. (313 aa)    
Predicted Functional Partners:
AFE_0540
Adenine phosphoribosyltransferase, putative; Identified by similarity to SP:Q59049; match to protein family HMM PF00156.
  
 0.952
purB
Adenylosuccinate lyase; Identified by similarity to SP:P12047; match to protein family HMM PF00206; match to protein family HMM TIGR00928; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
  
 0.936
AFE_0403
Conserved hypothetical protein; Identified by similarity to GB:AAN48171.1.
  
  
  0.921
adk
Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.
  
 0.919
AFE_0432
Conserved hypothetical protein TIGR00726; Identified by similarity to GB:AAQ59864.1; match to protein family HMM PF02578; match to protein family HMM TIGR00726; Belongs to the multicopper oxidase YfiH/RL5 family.
  
  
  0.911
surE
Acid phosphatase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
     
  0.900
hisA
Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by similarity to SP:O35006; match to protein family HMM PF00977; match to protein family HMM TIGR00007.
  
    0.754
ahcY
Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
 
 
 0.602
purA
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
  
 
 0.588
sod
Superoxide dismutase; Identified by similarity to SP:Q03300; match to protein family HMM PF02777.
    
 
 0.573
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
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