| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AFE_0546 | AFE_0549 | AFE_0546 | AFE_0549 | Conserved hypothetical protein; Identified by similarity to GB:AAO91158.1. | Conserved hypothetical protein; Identified by similarity to PIR:E82325. | 0.497 |
| AFE_0546 | glnE | AFE_0546 | AFE_0548 | Conserved hypothetical protein; Identified by similarity to GB:AAO91158.1. | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.785 |
| AFE_0546 | ilvE | AFE_0546 | AFE_0547 | Conserved hypothetical protein; Identified by similarity to GB:AAO91158.1. | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.807 |
| AFE_0549 | AFE_0546 | AFE_0549 | AFE_0546 | Conserved hypothetical protein; Identified by similarity to PIR:E82325. | Conserved hypothetical protein; Identified by similarity to GB:AAO91158.1. | 0.497 |
| AFE_0549 | glnE | AFE_0549 | AFE_0548 | Conserved hypothetical protein; Identified by similarity to PIR:E82325. | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.546 |
| AFE_0549 | ilvE | AFE_0549 | AFE_0547 | Conserved hypothetical protein; Identified by similarity to PIR:E82325. | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.513 |
| AFE_1468 | glnE | AFE_1468 | AFE_0548 | Antioxidant, AhpC/Tsa family; Identified by match to protein family HMM PF00578; match to protein family HMM PF08534. | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.590 |
| AFE_3000 | glnE | AFE_3000 | AFE_0548 | Identified by similarity to SP:Q60176; match to protein family HMM PF00056. | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.518 |
| AFE_3000 | gltB | AFE_3000 | AFE_0730 | Identified by similarity to SP:Q60176; match to protein family HMM PF00056. | Glutamate synthase, large subunit; Identified by similarity to SP:P09831; match to protein family HMM PF00310; match to protein family HMM PF01493; match to protein family HMM PF01645; match to protein family HMM PF04898. | 0.873 |
| AFE_3000 | sucD | AFE_3000 | AFE_0427 | Identified by similarity to SP:Q60176; match to protein family HMM PF00056. | succinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. | 0.783 |
| glnA | glnD | AFE_0466 | AFE_0924 | Glutamine synthetase, type I; Identified by similarity to SP:P06711; match to protein family HMM PF00120; match to protein family HMM PF03951; match to protein family HMM TIGR00653. | protein-P-II uridylyltransferase; Identified by match to protein family HMM PF01842; match to protein family HMM PF01966; match to protein family HMM PF08335; match to protein family HMM TIGR01693. | 0.737 |
| glnA | glnE | AFE_0466 | AFE_0548 | Glutamine synthetase, type I; Identified by similarity to SP:P06711; match to protein family HMM PF00120; match to protein family HMM PF03951; match to protein family HMM TIGR00653. | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.888 |
| glnA | gltB | AFE_0466 | AFE_0730 | Glutamine synthetase, type I; Identified by similarity to SP:P06711; match to protein family HMM PF00120; match to protein family HMM PF03951; match to protein family HMM TIGR00653. | Glutamate synthase, large subunit; Identified by similarity to SP:P09831; match to protein family HMM PF00310; match to protein family HMM PF01493; match to protein family HMM PF01645; match to protein family HMM PF04898. | 0.953 |
| glnA | ntrC | AFE_0466 | AFE_2901 | Glutamine synthetase, type I; Identified by similarity to SP:P06711; match to protein family HMM PF00120; match to protein family HMM PF03951; match to protein family HMM TIGR00653. | Nitrogen regulation protein NR(I); Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes. | 0.523 |
| glnD | glnA | AFE_0924 | AFE_0466 | protein-P-II uridylyltransferase; Identified by match to protein family HMM PF01842; match to protein family HMM PF01966; match to protein family HMM PF08335; match to protein family HMM TIGR01693. | Glutamine synthetase, type I; Identified by similarity to SP:P06711; match to protein family HMM PF00120; match to protein family HMM PF03951; match to protein family HMM TIGR00653. | 0.737 |
| glnD | glnE | AFE_0924 | AFE_0548 | protein-P-II uridylyltransferase; Identified by match to protein family HMM PF01842; match to protein family HMM PF01966; match to protein family HMM PF08335; match to protein family HMM TIGR01693. | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.919 |
| glnD | gltB | AFE_0924 | AFE_0730 | protein-P-II uridylyltransferase; Identified by match to protein family HMM PF01842; match to protein family HMM PF01966; match to protein family HMM PF08335; match to protein family HMM TIGR01693. | Glutamate synthase, large subunit; Identified by similarity to SP:P09831; match to protein family HMM PF00310; match to protein family HMM PF01493; match to protein family HMM PF01645; match to protein family HMM PF04898. | 0.465 |
| glnD | ntrC | AFE_0924 | AFE_2901 | protein-P-II uridylyltransferase; Identified by match to protein family HMM PF01842; match to protein family HMM PF01966; match to protein family HMM PF08335; match to protein family HMM TIGR01693. | Nitrogen regulation protein NR(I); Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes. | 0.464 |
| glnE | AFE_0546 | AFE_0548 | AFE_0546 | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | Conserved hypothetical protein; Identified by similarity to GB:AAO91158.1. | 0.785 |
| glnE | AFE_0549 | AFE_0548 | AFE_0549 | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | Conserved hypothetical protein; Identified by similarity to PIR:E82325. | 0.546 |
