Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
trxThioredoxin; Identified by match to protein family HMM PF00085; match to protein family HMM TIGR01068; Belongs to the thioredoxin family. (108 aa)    
Predicted Functional Partners:
trxB
Thioredoxin-disulfide reductase; Identified by match to protein family HMM PF00070; match to protein family HMM PF07992; match to protein family HMM TIGR01292.
 
 0.995
cysH
Adenylylsulfate reductase, thioredoxin dependent; Reduction of activated sulfate into sulfite.
    
 
 0.820
groEL
Chaperonin, 60 kDa; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
  
 
 0.735
arsC
Arsenate reductase; Identified by similarity to GB:AAF69239.1; match to protein family HMM PF01451; Belongs to the low molecular weight phosphotyrosine protein phosphatase family.
  
 
 0.725
rho
Transcription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template.
  
    0.662
nrdA
Ribonucleotide-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
  
 
 0.594
dsbD
Thiol:disulfide interchange protein DsbD; Identified by similarity to SP:P36655; match to protein family HMM PF02683.
   
 
 0.572
AFE_0985
Antioxidant, AhpC/Tsa family; Identified by match to protein family HMM PF00578; match to protein family HMM PF08534.
  
 
 0.553
gltB
Glutamate synthase, large subunit; Identified by similarity to SP:P09831; match to protein family HMM PF00310; match to protein family HMM PF01493; match to protein family HMM PF01645; match to protein family HMM PF04898.
    
 
 0.551
pdhC
Pyruvate dehydrogenase complex, E2 and E3 components; Dihydrolipoamide acetyltransferase/dihydrolipoamide dehydrogenase; identified by similarity to PIR:C59237; match to protein family HMM PF00070; match to protein family HMM PF00198; match to protein family HMM PF00364; match to protein family HMM PF02817; match to protein family HMM PF02852; match to protein family HMM PF07992.
  
 
 0.528
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
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