Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Neighborhood
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
AFE_0693Sigma-54 dependent transcriptional regulator; Identified by match to protein family HMM PF00158; match to protein family HMM PF02954; match to protein family HMM PF07728. (643 aa)    
Predicted Functional Partners:
rpoN
RNA polymerase sigma-54 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
  
  
 0.937
AFE_0695
Hypothetical protein; Identified by glimmer; putative.
       0.752
AFE_1694
Conjugal transfer protein; Identified by similarity to SP:P54914.
      
 0.724
AFE_0692
Oxidoreductase alpha (molybdopterin) subunit; Identified by match to protein family HMM PF00384; match to protein family HMM PF01568; match to protein family HMM TIGR01701; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.
       0.473
AFE_1497
Conserved hypothetical protein; Identified by match to protein family HMM PF03573.
      
 0.450
AFE_1991
Conserved hypothetical protein; Identified by similarity to GB:BAC50343.1; match to protein family HMM PF03573.
      
 0.450
glyQ
glycyl-tRNA synthetase, alpha subunit; Identified by similarity to SP:P00960; match to protein family HMM PF02091; match to protein family HMM TIGR00388.
      
 0.450
gph-2
Phosphoglycolate phosphatase; Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress. Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.
      
 0.450
AFE_0719
Amino acid permease family protein; Identified by match to protein family HMM PF00324.
      
 0.443
AFE_2644
Identified by match to protein family HMM PF00753.
      
 0.443
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
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