Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
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AFE_0705Hydrogenase maturation protease; Identified by match to protein family HMM TIGR00072. (157 aa)    
Predicted Functional Partners:
hybC
Hydrogenase-2, large subunit; Identified by match to protein family HMM PF00374.
 
 
 0.914
AFE_0707
Conserved hypothetical protein; Identified by similarity to PIR:AI1892.
 
     0.894
hybA
Hydrogenase-2, small subunit; Identified by match to protein family HMM PF01058.
 
  
 0.885
AFE_0711
NHL repeat protein; Identified by match to protein family HMM PF01436.
 
     0.864
AFE_0710
Iron-sulfur cluster-binding protein, Rieske family; Identified by match to protein family HMM PF00355; match to protein family HMM PF01106.
 
     0.845
AFE_0706
Hypothetical protein; Identified by glimmer; putative.
       0.799
AFE_0704
Hypothetical protein; Identified by glimmer; putative.
       0.789
AFE_0703
Conserved hypothetical protein; Identified by similarity to SP:P00264.
       0.748
hypC-1
Hydrogenase assembly chaperone HypC; Identified by similarity to SP:P24191; match to protein family HMM PF01455; match to protein family HMM TIGR00074.
 
  
 0.697
hypF
[NiFe] hydrogenase maturation protein HypF; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.
 
   
 0.635
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
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