Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AFE_0707Conserved hypothetical protein; Identified by similarity to PIR:AI1892. (326 aa)    
Predicted Functional Partners:
AFE_0710
Iron-sulfur cluster-binding protein, Rieske family; Identified by match to protein family HMM PF00355; match to protein family HMM PF01106.
 
  
 0.936
AFE_0711
NHL repeat protein; Identified by match to protein family HMM PF01436.
 
 
 
 0.914
AFE_0705
Hydrogenase maturation protease; Identified by match to protein family HMM TIGR00072.
 
     0.894
hybC
Hydrogenase-2, large subunit; Identified by match to protein family HMM PF00374.
 
     0.856
hybA
Hydrogenase-2, small subunit; Identified by match to protein family HMM PF01058.
 
     0.841
hypC-1
Hydrogenase assembly chaperone HypC; Identified by similarity to SP:P24191; match to protein family HMM PF01455; match to protein family HMM TIGR00074.
 
     0.797
AFE_2879
Conserved hypothetical protein; Identified by similarity to SP:P76395.
  
 
  0.731
AFE_0708
Hypothetical protein; Identified by glimmer; putative.
       0.693
AFE_1221
Modification methylase, putative; Identified by similarity to SP:P11409.
  
     0.673
AFE_0709
Membrane protein, putative.
       0.656
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
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