Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
AFE_0711NHL repeat protein; Identified by match to protein family HMM PF01436. (398 aa)    
Predicted Functional Partners:
AFE_0710
Iron-sulfur cluster-binding protein, Rieske family; Identified by match to protein family HMM PF00355; match to protein family HMM PF01106.
 
  
 0.953
AFE_0707
Conserved hypothetical protein; Identified by similarity to PIR:AI1892.
 
 
 
 0.914
hypC-1
Hydrogenase assembly chaperone HypC; Identified by similarity to SP:P24191; match to protein family HMM PF01455; match to protein family HMM TIGR00074.
 
     0.895
AFE_0705
Hydrogenase maturation protease; Identified by match to protein family HMM TIGR00072.
 
     0.864
hybC
Hydrogenase-2, large subunit; Identified by match to protein family HMM PF00374.
 
     0.832
hybA
Hydrogenase-2, small subunit; Identified by match to protein family HMM PF01058.
 
     0.822
AFE_1130
Hypothetical protein; Identified by glimmer; putative.
    
 
 0.818
hypF
[NiFe] hydrogenase maturation protein HypF; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.
       0.796
hypD-1
Hydrogenase expression/formation protein HypD; Identified by similarity to SP:P24192; match to protein family HMM PF01924; match to protein family HMM TIGR00075; Belongs to the HypD family.
 
     0.767
AFE_0709
Membrane protein, putative.
       0.759
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
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