Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
hypB-1Hydrogenase accessory protein HypB; Identified by similarity to SP:P24190; match to protein family HMM PF02492; match to protein family HMM TIGR00073. (257 aa)    
Predicted Functional Partners:
hypA-1
Hydrogenase nickel insertion protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
 
 
 0.946
hyfG
Hydrogenase-4, G subunit; Identified by similarity to SP:P77329; match to protein family HMM PF00329; match to protein family HMM PF00346.
   
 
 0.931
hypC-1
Hydrogenase assembly chaperone HypC; Identified by similarity to SP:P24191; match to protein family HMM PF01455; match to protein family HMM TIGR00074.
 
  
 0.903
hypA-2
Hydrogenase nickel insertion protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
 
 
 0.902
hypE
Hydrogenase expression/formation protein HypE; Identified by similarity to SP:P40595; match to protein family HMM PF00586; match to protein family HMM PF02769; match to protein family HMM TIGR02124.
 
  
 0.890
hypD-1
Hydrogenase expression/formation protein HypD; Identified by similarity to SP:P24192; match to protein family HMM PF01924; match to protein family HMM TIGR00075; Belongs to the HypD family.
 
  
 0.875
hypD-2
Hydrogenase expression/formation protein HypD; Identified by similarity to SP:P24192; match to protein family HMM PF01924; match to protein family HMM TIGR00075; Belongs to the HypD family.
 
  
 0.874
hypF
[NiFe] hydrogenase maturation protein HypF; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.
 
   
 0.833
AFE_0180
Peptidyl-prolyl cis-trans isomerase, FKBP-type; Identified by similarity to SP:P30856; match to protein family HMM PF00254.
    
 
 0.702
gmhA
Phosphoheptose isomerase; Identified by similarity to SP:Q9AGY7; match to protein family HMM TIGR00441.
     
 0.702
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
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