Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AFE_0759Methyltransferase, putative; Identified by match to protein family HMM PF08241; match to protein family HMM PF08242. (216 aa)    
Predicted Functional Partners:
atpC-2
ATP synthase F1, epsilon subunit, putative; Produces ATP from ADP in the presence of a proton gradient across the membrane.
 
     0.764
ligA
DNA ligase, NAD-dependent; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
       0.728
AFE_0756
HAD-superfamily subfamily IB hydrolase, TIGR01490; Identified by similarity to GB:AAN70712.1; match to protein family HMM PF00702; match to protein family HMM TIGR01488; match to protein family HMM TIGR01490.
   
   0.529
AFE_0620
Hypothetical protein; Identified by glimmer; putative.
  
     0.467
AFE_1755
Conserved hypothetical protein; Identified by similarity to GB:AAN66820.1.
  
     0.448
AFE_2352
Conserved hypothetical protein; Identified by similarity to GB:BAC47910.1; match to protein family HMM PF00891; match to protein family HMM PF08241; match to protein family HMM PF08242.
 
   
 0.427
tetH
Tetrathionate hydrolase; Catalyzes the hydrolysis of tetrathionate to generate elemental sulfur, thiosulfate and sulfate.
  
     0.404
AFE_3010
Polyketide synthase, type I, putative; Identified by similarity to GB:AAK26474.1; match to protein family HMM PF00106; match to protein family HMM PF00107; match to protein family HMM PF00109; match to protein family HMM PF00550; match to protein family HMM PF00698; match to protein family HMM PF02801; match to protein family HMM PF08240; match to protein family HMM PF08659.
   
 
 0.400
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
Server load: low (10%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.