Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AFE_0786Heme-utilization protein HutZ, putative; Identified by similarity to GB:AAG23392.1; match to protein family HMM PF01243. (173 aa)    
Predicted Functional Partners:
hemH
Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.
     
 0.907
cyoE-1
Protoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
     
  0.900
bfr
Bacterioferritin; Identified by match to protein family HMM PF00210.
     
  0.900
AFE_0707
Conserved hypothetical protein; Identified by similarity to PIR:AI1892.
  
     0.566
AFE_0787
Identified by match to protein family HMM PF01522.
       0.560
AFE_0711
NHL repeat protein; Identified by match to protein family HMM PF01436.
  
     0.536
AFE_2577
Conserved hypothetical protein; Identified by similarity to PIR:A81195.
  
     0.492
hybC
Hydrogenase-2, large subunit; Identified by match to protein family HMM PF00374.
  
     0.481
AFE_0401
roadblock/LC7 domain protein; Identified by match to protein family HMM PF03259.
  
     0.477
AFE_2578
roadblock/LC7 domain protein; Identified by match to protein family HMM PF03259.
  
     0.447
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.