STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (189 aa)    
Predicted Functional Partners:
pyrF
Orotidine 5`-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily.
  
 
 0.997
pyrD
Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
  
 0.994
carB
Carbamoyl-phosphate synthase, large subunit; Identified by similarity to SP:P00968; match to protein family HMM PF00289; match to protein family HMM PF02142; match to protein family HMM PF02222; match to protein family HMM PF02655; match to protein family HMM PF02786; match to protein family HMM PF02787; match to protein family HMM TIGR01369; Belongs to the CarB family.
  
 
 0.960
pyrB
Aspartate carbamoyltransferase; Identified by similarity to SP:Q59711; match to protein family HMM PF00185; match to protein family HMM PF02729; match to protein family HMM TIGR00670; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
  
  
 0.940
carA
Carbamoyl-phosphate synthase, small subunit; Identified by similarity to SP:P00907; match to protein family HMM PF00117; match to protein family HMM PF00988; match to protein family HMM TIGR01368; Belongs to the CarA family.
  
  
 0.927
pyrR
PyrR bifunctional protein; Identified by similarity to SP:P39765; match to protein family HMM PF00156.
  
  
 0.900
prsA
Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
 
 
 0.886
AFE_0252
CDP-6-deoxy-L-threo-D-glycero-4-hexulose-3- dehydrase reductase, putative; Identified by similarity to SP:P37911; match to protein family HMM PF00111; match to protein family HMM PF00175; match to protein family HMM PF00970.
  
  
 0.857
AFE_1656
Ferredoxin/oxidoreductase, FAD/NAD-binding; Identified by match to protein family HMM PF00111; match to protein family HMM PF00175; match to protein family HMM PF00970.
  
  
 0.857
pyrC-2
Dihydroorotase, multifunctional complex type; Identified by similarity to SP:P81006; match to protein family HMM PF01979; match to protein family HMM TIGR00857.
  
  
 0.835
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
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