Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-expression
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[Homology]
Score
hoxH[NiFe] hydrogenase, alpha subunit, putative; Identified by similarity to GB:BAC00531.1; match to protein family HMM PF00374. (422 aa)    
Predicted Functional Partners:
hoxY
[NiFe] hydrogenase, delta subunit, putative; Identified by similarity to GB:BAC00530.1; match to protein family HMM PF01058.
 
 
 0.994
hoxF
[NiFe] hydrogenase, beta subunit, putative; Identified by similarity to GB:BAC00528.1; match to protein family HMM PF00037.
 
   
 0.975
hoxW
Hydrogenase maturation protease.
 
  
 0.957
hoxU
[NiFe] hydrogenase, gamma subunit, putative; Identified by similarity to GB:BAC00529.1; match to protein family HMM PF00175; match to protein family HMM PF00970.
 
   
 0.948
AFE_1512
Ferredoxin; Identified by similarity to SP:P46036; match to protein family HMM PF00037; match to protein family HMM TIGR02936.
   
   0.788
AFE_0935
Hypothetical protein; Identified by glimmer; putative.
       0.773
hynD
Hydrogenase maturation protease; Identified by match to protein family HMM PF01750; match to protein family HMM TIGR00072.
 
  
 0.667
hypF
[NiFe] hydrogenase maturation protein HypF; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.
 
   
 0.662
hypD-2
Hydrogenase expression/formation protein HypD; Identified by similarity to SP:P24192; match to protein family HMM PF01924; match to protein family HMM TIGR00075; Belongs to the HypD family.
 
   
 0.660
hypE
Hydrogenase expression/formation protein HypE; Identified by similarity to SP:P40595; match to protein family HMM PF00586; match to protein family HMM PF02769; match to protein family HMM TIGR02124.
 
   
 0.630
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
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