Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
hoxF[NiFe] hydrogenase, beta subunit, putative; Identified by similarity to GB:BAC00528.1; match to protein family HMM PF00037. (368 aa)    
Predicted Functional Partners:
hoxU
[NiFe] hydrogenase, gamma subunit, putative; Identified by similarity to GB:BAC00529.1; match to protein family HMM PF00175; match to protein family HMM PF00970.
  
 0.993
hoxH
[NiFe] hydrogenase, alpha subunit, putative; Identified by similarity to GB:BAC00531.1; match to protein family HMM PF00374.
 
   
 0.975
hoxW
Hydrogenase maturation protease.
 
   
 0.968
hoxY
[NiFe] hydrogenase, delta subunit, putative; Identified by similarity to GB:BAC00530.1; match to protein family HMM PF01058.
 
   
 0.959
AFE_0935
Hypothetical protein; Identified by glimmer; putative.
       0.752
isp1
Membrane protein, putative.
 
 
 0.584
AFE_0941
Murein transglycosylase, putative; Identified by similarity to SP:P03810; match to protein family HMM PF01464.
       0.572
hynD
Hydrogenase maturation protease; Identified by match to protein family HMM PF01750; match to protein family HMM TIGR00072.
 
   
 0.549
hypF
[NiFe] hydrogenase maturation protein HypF; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.
 
   
 0.524
isp2
Iron-sulfur cluster-binding protein; Identified by match to protein family HMM PF00037; match to protein family HMM PF02754.
  
   
 0.524
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
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