Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AFE_0958Pyridine nucleotide-disulfide oxidoreductase; Identified by match to protein family HMM PF00070; match to protein family HMM PF02852; match to protein family HMM PF07992. (472 aa)    
Predicted Functional Partners:
AFE_1811
2-oxo acid dehydrogenase, acyltransferase, putative; Identified by match to protein family HMM PF00198; match to protein family HMM PF00364; match to protein family HMM PF02817.
 
 0.988
pdhC
Pyruvate dehydrogenase complex, E2 and E3 components; Dihydrolipoamide acetyltransferase/dihydrolipoamide dehydrogenase; identified by similarity to PIR:C59237; match to protein family HMM PF00070; match to protein family HMM PF00198; match to protein family HMM PF00364; match to protein family HMM PF02817; match to protein family HMM PF02852; match to protein family HMM PF07992.
 
0.981
AFE_1812
Dehydrogenase complex, E1 component, beta subunit, putative; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.
 
 0.978
pdhB
Pyruvate dehydrogenase, E1 component, pyruvate dehydrogenase beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.
 
 0.978
gcvH-2
Glycine cleavage system H protein, putative; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
 
 
 0.966
AFE_2549
Glycine cleavage system protein H, putative; Identified by similarity to SP:P23884; match to protein family HMM PF01597.
 
 
  0.964
gcvH-3
Glycine cleavage system H protein, putative; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
 
 
  0.961
gcvH
Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
 
 
 0.957
AFE_1813
Dehydrogenase complex, E1 component, alpha subunit, putative; Identified by match to protein family HMM PF00676.
 
 
 0.956
pdhA
Pyruvate dehydrogenase complex, E1 component, pyruvate dehydrogenase alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
 
 
 0.956
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
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