Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
AFE_1012Hypothetical protein; Identified by glimmer; putative. (91 aa)    
Predicted Functional Partners:
topA-2
DNA topoisomerase I, putative; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removin [...]
       0.773
AFE_1006
Hypothetical protein; Identified by glimmer; putative.
       0.513
AFE_1007
Transglycosylase, putative; Identified by match to protein family HMM PF01464.
       0.513
AFE_1008
Hypothetical protein; Identified by glimmer; putative.
       0.513
AFE_1009
Hypothetical protein; Identified by glimmer; putative.
       0.513
AFE_1010
Hypothetical protein; Identified by glimmer; putative.
       0.513
AFE_1011
Hypothetical protein; Identified by glimmer; putative.
       0.513
AFE_1014
Hypothetical protein; Identified by glimmer; putative.
       0.481
AFE_1015
Hypothetical protein; Identified by glimmer; putative.
       0.481
AFE_1016
Lipoprotein, putative.
       0.481
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
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