Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AFE_1229EAL domain protein; Identified by match to protein family HMM PF00563. (228 aa)    
Predicted Functional Partners:
AFE_1725
Sensory box-containing diguanylate cyclase, putative; Identified by match to protein family HMM PF00563; match to protein family HMM PF00989; match to protein family HMM PF00990; match to protein family HMM PF08448; match to protein family HMM TIGR00229; match to protein family HMM TIGR00254.
 
 
 0.857
AFE_3057
Sensory box-containing diguanylate cyclase, putative; Identified by match to protein family HMM PF00563; match to protein family HMM PF00990; match to protein family HMM PF01590; match to protein family HMM PF08447; match to protein family HMM TIGR00229; match to protein family HMM TIGR00254.
 
  
 0.856
AFE_1707
Sensory box-containing diguanylate cyclase, putative; Identified by match to protein family HMM PF00563; match to protein family HMM PF00989; match to protein family HMM PF00990; match to protein family HMM PF01590; match to protein family HMM PF08447; match to protein family HMM PF08448; match to protein family HMM TIGR00229; match to protein family HMM TIGR00254.
 
 
 0.855
ligA-2
DNA ligase, NAD-dependent, putative; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
       0.773
AFE_1231
Hypothetical protein; Identified by glimmer; putative.
       0.773
AFE_1595
Hypothetical protein; Identified by glimmer; putative.
 
 
 0.677
AFE_1915
Type IV pilus assembly protein PilZ, putative; Identified by similarity to PIR:B59241; match to protein family HMM PF07238.
    
   0.657
AFE_1710
Hypothetical protein; Identified by glimmer; putative.
  
  
 0.651
AFE_0191
Transcriptional regulator, Fis family; Identified by match to protein family HMM PF02954; Belongs to the transcriptional regulatory Fis family.
    
 
 0.585
AFE_1712
Diguanylate cyclase, putative; Identified by match to protein family HMM PF00563; match to protein family HMM PF00990; match to protein family HMM TIGR00254.
 
   
0.430
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
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