Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AFE_1258DNA topoisomerase domain protein. (429 aa)    
Predicted Functional Partners:
recQ
ATP-dependent DNA helicase RecQ; Identified by similarity to SP:P15043; match to protein family HMM PF00270; match to protein family HMM PF00271; match to protein family HMM PF00570; match to protein family HMM TIGR00614; match to protein family HMM TIGR01389.
   
 0.814
AFE_1257
Hypothetical protein; Identified by glimmer; putative.
       0.777
AFE_1259
Hypothetical protein; Identified by glimmer; putative.
       0.723
recA
recA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
    
 0.603
polI
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
   
 0.583
ssb-3
Single-strand binding protein; Identified by match to protein family HMM PF00436; match to protein family HMM TIGR00621.
   
 
 0.569
AFE_0942
DNA helicase, SNF2/RAD54 family; Identified by match to protein family HMM PF00176; match to protein family HMM PF00271; match to protein family HMM PF04434.
 
 
 
 0.562
rpoC
DNA-directed RNA polymerase, beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
   
 
 0.546
AFE_1371
Helicase, SNF2/RAD54 family; Identified by match to protein family HMM PF00176; match to protein family HMM PF00271.
  
 
 
 0.534
AFE_1261
Hypothetical protein; Identified by glimmer; putative.
       0.471
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
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