Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AFE_1297Cobalamin biosynthesis protein, CobS family; Identified by match to protein family HMM PF07728. (306 aa)    
Predicted Functional Partners:
AFE_1292
Conserved hypothetical protein; Identified by similarity to GB:AAL59705.1.
 
  
 0.716
AFE_2535
Von Willebrand factor type A domain protein.
 
 
 0.688
AFE_3054
Von Willebrand factor type A domain protein; Identified by match to protein family HMM PF00092.
 
 
 0.630
AFE_1677
Von Willebrand factor type A domain protein; Identified by match to protein family HMM PF00092.
 
 
 0.626
AFE_1275
Conserved hypothetical protein.
 
    0.612
AFE_2157
Von Willebrand factor type A domain protein; Identified by match to protein family HMM PF00092.
 
 
 0.586
AFE_1296
Transcriptional regulator, LysR family; Identified by similarity to SP:Q47083; match to protein family HMM PF00126; match to protein family HMM PF03466; Belongs to the LysR transcriptional regulatory family.
  
    0.478
AFE_1095
Pilus assembly protein TraW, putative; Identified by similarity to SP:P18472.
  
    0.475
AFE_1298
Hypothetical protein; Identified by glimmer; putative.
       0.460
AFE_1299
Hypothetical protein; Identified by glimmer; putative.
       0.446
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
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