Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AFE_1365HNH endonuclease domain protein; Identified by match to protein family HMM PF01844. (471 aa)    
Predicted Functional Partners:
AFE_1304
Transposon, resolvase; A gene for transposase is adjacent; identified by match to protein family HMM PF00239; match to protein family HMM PF00376.
  
     0.698
AFE_1033
Transposon, resolvase; Adjacent to a gene for transposase; identified by match to protein family HMM PF00239.
  
     0.630
AFE_1366
Mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Identified by similarity to SP:P29956; match to protein family HMM PF00483; match to protein family HMM PF01050; match to protein family HMM PF07883; match to protein family HMM TIGR01479; Belongs to the mannose-6-phosphate isomerase type 2 family.
       0.596
AFE_1105
Transposon, resolvase; Adjacent to a gene for transposase; identified by match to protein family HMM PF00239.
  
     0.559
AFE_1215
ISAfe8, transposase; Identified by match to protein family HMM PF01385; match to protein family HMM PF07282; match to protein family HMM TIGR01766.
  
     0.523
AFE_1058
ISAfe8, transposase; Identified by match to protein family HMM PF01385; match to protein family HMM PF07282; match to protein family HMM TIGR01766.
  
     0.520
AFE_1034
Transposon, transposase; Adjacent to a gene for resolvase; identified by match to protein family HMM PF07282.
  
     0.433
vapC-4
PIN domain protein; Toxic component of a toxin-antitoxin (TA) system. An RNase. Belongs to the PINc/VapC protein family.
 
     0.430
AFE_1363
Nucleotidyltransferase, putative; Identified by match to protein family HMM PF01909.
       0.400
AFE_1364
Conserved hypothetical protein; Identified by similarity to GB:CAE06995.1; match to protein family HMM PF05168.
       0.400
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
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