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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
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[Homology]
Score
ppxExopolyphosphatase; Identified by similarity to SP:Q9ZN70; match to protein family HMM PF02541. (503 aa)    
Predicted Functional Partners:
ppk
Polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family.
 
 
 0.974
pstA
Phosphate ABC transporter, permease protein PstA; Identified by similarity to SP:P07654; match to protein family HMM PF00528; match to protein family HMM TIGR00974.
     
 0.939
spoT
Guanosine-3,5-bis(diphosphate) 3-pyrophosphohydrolase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.
  
 
 0.936
phoU
Phosphate transport system protein PhoU; Plays a role in the regulation of phosphate uptake.
     
 0.925
pstB
Phosphate ABC transporter, ATP-binding protein; Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
     
 0.912
pstC-2
Phosphate ABC transporter, permease protein PstC; Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
     
 0.875
AFE_1892
Conserved hypothetical protein; Identified by similarity to PIR:E83627; match to protein family HMM PF03976.
 
 
 0.813
AFE_1442
Hypothetical protein; Identified by glimmer; putative.
       0.773
ppnK
ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
      
 0.761
phoR
Phosphate regulon sensor protein PhoR; Identified by similarity to SP:P08400; match to protein family HMM PF00512; match to protein family HMM PF02518; match to protein family HMM TIGR02966.
     
 0.723
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
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