Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Score
AFE_1544Pyrophosphorylase, putative; Identified by similarity to SP:P59245; match to protein family HMM PF01729; match to protein family HMM PF02749; match to protein family HMM TIGR01334; Belongs to the NadC/ModD family. (284 aa)    
Predicted Functional Partners:
nadA
Quinolinate synthetase complex, subunit A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
 
  
 0.953
nadB
L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate.
 
  
 0.946
AFE_1545
Molybdenum-pterin binding protein; Identified by match to protein family HMM PF03459; match to protein family HMM TIGR00638.
       0.526
purL
Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.
  
  
 0.466
nadE
Glutamine-dependent NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
  
  
 0.454
ribD
Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.
     
 0.446
AFE_1546
Succinate-semialdehyde dehydrogenase, putative; Identified by similarity to SP:P25526; match to protein family HMM PF00171.
  
  
 0.418
AFE_0227
Mutator mutT protein/thiamine-phosphate pyrophosphorylase family protein; Identified by match to protein family HMM PF00293; match to protein family HMM PF02581; match to protein family HMM TIGR00586; Belongs to the Nudix hydrolase family.
     
 0.401
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
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