Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AFE_1576Type I restriction-modification system, S subunit; Identified by match to protein family HMM PF01420. (399 aa)    
Predicted Functional Partners:
AFE_1577
Type I restriction-modification system, M subunit; Identified by match to protein family HMM PF02384.
 
   0.975
AFE_1575
Type I restriction-modification system, R subunit; Identified by similarity to SP:P08956; match to protein family HMM PF04313; match to protein family HMM PF04851; match to protein family HMM PF08463.
 
 
 0.962
AFE_0684
Type I restriction-modification system, M subunit; Identified by similarity to SP:Q47282; match to protein family HMM PF02384.
 
   0.846
AFE_0683
Type I restriction-modification system, R subunit; Identified by similarity to SP:Q47281; match to protein family HMM PF00271; match to protein family HMM PF04313; match to protein family HMM PF04851; match to protein family HMM PF08463.
 
 
 0.730
AFE_0826
Type I restriction-modification system, M subunit; Identified by match to protein family HMM PF02384.
 
   0.648
AFE_1415
Conserved domain protein; Identified by similarity to GB:BAC17067.1.
  
   0.572
AFE_2372
Type I restriction-modification system, M subunit; Identified by match to protein family HMM PF02384; match to protein family HMM TIGR00497.
  
   0.572
AFE_2793
Type I restriction-modification system, M subunit; Identified by match to protein family HMM PF02384.
  
   0.572
AFE_1578
PIN domain protein; Identified by match to protein family HMM PF01850.
       0.529
AFE_1579
Conserved hypothetical protein; Identified by similarity to GB:AAK52344.1.
       0.529
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
Server load: low (34%) [HD]