Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AFE_1652Oxidoreductase alpha (molybdopterin) subunit; Identified by match to protein family HMM PF00384; match to protein family HMM PF01568; match to protein family HMM TIGR01701; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (755 aa)    
Predicted Functional Partners:
fdhD-1
Formate dehydrogenase family accessory protein FdhD; Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. Belongs to the FdhD family.
 
  
 0.974
sreB
Sulfur reductase, iron-sulfur binding subunit; Identified by similarity to GB:CAC86938.1; match to protein family HMM PF00037.
  
 
 0.895
AFE_1651
Identified by similarity to SP:O34969; match to protein family HMM PF03446; match to protein family HMM PF03807.
  
  
 0.868
fdhD-2
Formate dehydrogenase family accessory protein FdhD; Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. Belongs to the FdhD family.
 
  
 0.809
AFE_1653
Hypothetical protein; Identified by glimmer; putative.
       0.773
AFE_2553
Pyridine nucleotide-disulfide oxidoreductase; Identified by similarity to PIR:G70335; match to protein family HMM PF00070; match to protein family HMM PF07992.
   
 
 0.679
tuf-2
Translation elongation factor Tu; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis.
   
 
 0.669
tuf-1
Translation elongation factor Tu; Identified by similarity to SP:P48864; match to protein family HMM PF00009; match to protein family HMM PF03143; match to protein family HMM PF03144; match to protein family HMM TIGR00231; match to protein family HMM TIGR00485.
   
 
 0.669
AFE_2393
ISAfe5, transposase orfA; Identified by similarity to GB:AAB81643.1.
   
  
 0.607
AFE_1575
Type I restriction-modification system, R subunit; Identified by similarity to SP:P08956; match to protein family HMM PF04313; match to protein family HMM PF04851; match to protein family HMM PF08463.
      
 0.604
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.