Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Neighborhood
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
umuDumuD protein; Identified by similarity to SP:P04153; match to protein family HMM PF00717; Belongs to the peptidase S24 family. (164 aa)    
Predicted Functional Partners:
AFE_1751
umuC protein; Identified by match to protein family HMM PF00817.
 
 
 0.976
recA
recA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 
 0.938
dinB
DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.
 
 
 0.906
recN
DNA repair protein RecN; May be involved in recombinational repair of damaged DNA.
   
  
 0.649
recX
Regulatory protein RecX; Modulates RecA activity; Belongs to the RecX family.
   
  
 0.602
AFE_1869
Cell division inhibitor, putative; Identified by similarity to SP:P08845.
  
  
 0.596
AFE_1748
Hypothetical protein; Identified by glimmer; putative.
       0.572
AFE_1752
Conserved hypothetical protein; Identified by similarity to GB:AAO54594.1.
       0.568
clpP
ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.
      
 0.508
AFE_1870
Conserved hypothetical protein; Identified by similarity to GB:AAM40399.1.
  
 
 0.505
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
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