guaB protein (Acidithiobacillus ferrooxidans)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Acidithiobacillus ferrooxidans

NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFE_0364	AFE_2530	AFE_0364	AFE_2530	Hypoxanthine-guanine phosphoribosyltransferase, putative; Identified by similarity to SP:P37472; match to protein family HMM PF00156.	Conserved hypothetical protein; Identified by similarity to GB:AAQ61408.1.	0.914
AFE_0364	guaA	AFE_0364	AFE_1778	Hypoxanthine-guanine phosphoribosyltransferase, putative; Identified by similarity to SP:P37472; match to protein family HMM PF00156.	GMP synthase; Catalyzes the synthesis of GMP from XMP.	0.944
AFE_0364	guaB	AFE_0364	AFE_1777	Hypoxanthine-guanine phosphoribosyltransferase, putative; Identified by similarity to SP:P37472; match to protein family HMM PF00156.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.	0.942
AFE_0364	purA	AFE_0364	AFE_1889	Hypoxanthine-guanine phosphoribosyltransferase, putative; Identified by similarity to SP:P37472; match to protein family HMM PF00156.	Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.	0.945
AFE_0364	purH	AFE_0364	AFE_2260	Hypoxanthine-guanine phosphoribosyltransferase, putative; Identified by similarity to SP:P37472; match to protein family HMM PF00156.	Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Identified by similarity to SP:P15639; match to protein family HMM PF01808; match to protein family HMM PF02142; match to protein family HMM TIGR00355.	0.921
AFE_0364	purK	AFE_0364	AFE_0273	Hypoxanthine-guanine phosphoribosyltransferase, putative; Identified by similarity to SP:P37472; match to protein family HMM PF00156.	Phosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).	0.409
AFE_0364	rdgB	AFE_0364	AFE_2341	Hypoxanthine-guanine phosphoribosyltransferase, putative; Identified by similarity to SP:P37472; match to protein family HMM PF00156.	Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.	0.901
AFE_0364	surE	AFE_0364	AFE_0468	Hypoxanthine-guanine phosphoribosyltransferase, putative; Identified by similarity to SP:P37472; match to protein family HMM PF00156.	Acid phosphatase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.	0.924
AFE_2530	AFE_0364	AFE_2530	AFE_0364	Conserved hypothetical protein; Identified by similarity to GB:AAQ61408.1.	Hypoxanthine-guanine phosphoribosyltransferase, putative; Identified by similarity to SP:P37472; match to protein family HMM PF00156.	0.914
AFE_2530	carB	AFE_2530	AFE_0639	Conserved hypothetical protein; Identified by similarity to GB:AAQ61408.1.	Carbamoyl-phosphate synthase, large subunit; Identified by similarity to SP:P00968; match to protein family HMM PF00289; match to protein family HMM PF02142; match to protein family HMM PF02222; match to protein family HMM PF02655; match to protein family HMM PF02786; match to protein family HMM PF02787; match to protein family HMM TIGR01369; Belongs to the CarB family.	0.575
AFE_2530	guaA	AFE_2530	AFE_1778	Conserved hypothetical protein; Identified by similarity to GB:AAQ61408.1.	GMP synthase; Catalyzes the synthesis of GMP from XMP.	0.904
AFE_2530	guaB	AFE_2530	AFE_1777	Conserved hypothetical protein; Identified by similarity to GB:AAQ61408.1.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.	0.966
AFE_2530	rdgB	AFE_2530	AFE_2341	Conserved hypothetical protein; Identified by similarity to GB:AAQ61408.1.	Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.	0.902
AFE_2530	ribBA	AFE_2530	AFE_0299	Conserved hypothetical protein; Identified by similarity to GB:AAQ61408.1.	3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family.	0.402
AFE_2530	surE	AFE_2530	AFE_0468	Conserved hypothetical protein; Identified by similarity to GB:AAQ61408.1.	Acid phosphatase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.	0.911
carB	AFE_2530	AFE_0639	AFE_2530	Carbamoyl-phosphate synthase, large subunit; Identified by similarity to SP:P00968; match to protein family HMM PF00289; match to protein family HMM PF02142; match to protein family HMM PF02222; match to protein family HMM PF02655; match to protein family HMM PF02786; match to protein family HMM PF02787; match to protein family HMM TIGR01369; Belongs to the CarB family.	Conserved hypothetical protein; Identified by similarity to GB:AAQ61408.1.	0.575
carB	guaA	AFE_0639	AFE_1778	Carbamoyl-phosphate synthase, large subunit; Identified by similarity to SP:P00968; match to protein family HMM PF00289; match to protein family HMM PF02142; match to protein family HMM PF02222; match to protein family HMM PF02655; match to protein family HMM PF02786; match to protein family HMM PF02787; match to protein family HMM TIGR01369; Belongs to the CarB family.	GMP synthase; Catalyzes the synthesis of GMP from XMP.	0.968
carB	guaB	AFE_0639	AFE_1777	Carbamoyl-phosphate synthase, large subunit; Identified by similarity to SP:P00968; match to protein family HMM PF00289; match to protein family HMM PF02142; match to protein family HMM PF02222; match to protein family HMM PF02655; match to protein family HMM PF02786; match to protein family HMM PF02787; match to protein family HMM TIGR01369; Belongs to the CarB family.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.	0.962
carB	purA	AFE_0639	AFE_1889	Carbamoyl-phosphate synthase, large subunit; Identified by similarity to SP:P00968; match to protein family HMM PF00289; match to protein family HMM PF02142; match to protein family HMM PF02222; match to protein family HMM PF02655; match to protein family HMM PF02786; match to protein family HMM PF02787; match to protein family HMM TIGR01369; Belongs to the CarB family.	Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.	0.957
carB	purH	AFE_0639	AFE_2260	Carbamoyl-phosphate synthase, large subunit; Identified by similarity to SP:P00968; match to protein family HMM PF00289; match to protein family HMM PF02142; match to protein family HMM PF02222; match to protein family HMM PF02655; match to protein family HMM PF02786; match to protein family HMM PF02787; match to protein family HMM TIGR01369; Belongs to the CarB family.	Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Identified by similarity to SP:P15639; match to protein family HMM PF01808; match to protein family HMM PF02142; match to protein family HMM TIGR00355.	0.452