Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Neighborhood
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
AFE_1874Adenylate cyclase; Identified by match to protein family HMM PF01928. (489 aa)    
Predicted Functional Partners:
AFE_1875
ParA-like protein; Identified by similarity to SP:P07175.
       0.785
ppk
Polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family.
       0.785
folD
Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
       0.770
AFE_2428
Heavy metal efflux system protein, putative; Identified by similarity to SP:P77214.
  
     0.527
AFE_2782
Cation efflux system protein, putative; Identified by similarity to SP:P77214.
  
     0.522
AFE_2896
Identified by match to protein family HMM PF04932.
  
     0.501
AFE_2134
Lipoprotein, putative; Identified by similarity to GB:CAD13844.1.
  
     0.435
AFE_1878
Transporter, AcrB/AcrD/AcrF family; Identified by match to protein family HMM PF00873; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
       0.421
AFE_1879
Efflux transporter, RND family, MFP subunit; Identified by match to protein family HMM PF00529; match to protein family HMM TIGR01730; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
       0.416
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
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