Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AFE_1875ParA-like protein; Identified by similarity to SP:P07175. (212 aa)    
Predicted Functional Partners:
ppk
Polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family.
  
    0.794
folD
Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
       0.791
AFE_1874
Adenylate cyclase; Identified by match to protein family HMM PF01928.
       0.785
AFE_1719
Identified by match to protein family HMM PF02195; match to protein family HMM TIGR00180; Belongs to the ParB family.
  
 
 0.600
AFE_3211
Identified by match to protein family HMM PF02195; match to protein family HMM TIGR00180; Belongs to the ParB family.
  
 
 0.600
AFE_0266
Glycosyl transferase, group 2 family protein; Identified by match to protein family HMM PF00535; match to protein family HMM TIGR03469.
 
 
 0.580
AFE_2121
Identified by match to protein family HMM PF00535; match to protein family HMM TIGR03472.
  
 
 0.483
AFE_2762
TPR domain protein; Identified by match to protein family HMM PF00515; match to protein family HMM PF07719; match to protein family HMM PF07721.
 
 
 0.438
AFE_1878
Transporter, AcrB/AcrD/AcrF family; Identified by match to protein family HMM PF00873; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
       0.425
AFE_1879
Efflux transporter, RND family, MFP subunit; Identified by match to protein family HMM PF00529; match to protein family HMM TIGR01730; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
       0.420
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
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