bioA protein (Acidithiobacillus ferrooxidans)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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co-expression

Genomic Predictions

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gene co-occurrence

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Your Current Organism:

Acidithiobacillus ferrooxidans

NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFE_1925	amtB	AFE_1925	AFE_1922	CBS domain protein; Identified by match to protein family HMM PF00571.	Identified by match to protein family HMM PF00909.	0.805
AFE_1925	bioA	AFE_1925	AFE_1924	CBS domain protein; Identified by match to protein family HMM PF00571.	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Identified by similarity to SP:P53555; match to protein family HMM PF00202; match to protein family HMM TIGR00508; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.805
AFE_1925	mutL	AFE_1925	AFE_1927	CBS domain protein; Identified by match to protein family HMM PF00571.	Mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.	0.746
AFE_1925	nnrD	AFE_1925	AFE_1923	CBS domain protein; Identified by match to protein family HMM PF00571.	YjeF-related protein; Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S-and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.	0.784
AFE_3011	bioA	AFE_3011	AFE_1924	8-amino-7-oxononanoate synthase, putative; Identified by match to protein family HMM PF00155; match to protein family HMM PF00202.	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Identified by similarity to SP:P53555; match to protein family HMM PF00202; match to protein family HMM TIGR00508; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.782
AFE_3011	bioB	AFE_3011	AFE_0259	8-amino-7-oxononanoate synthase, putative; Identified by match to protein family HMM PF00155; match to protein family HMM PF00202.	Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family.	0.794
AFE_3011	bioD-1	AFE_3011	AFE_1675	8-amino-7-oxononanoate synthase, putative; Identified by match to protein family HMM PF00155; match to protein family HMM PF00202.	Dethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring.	0.876
AFE_3011	bioD-2	AFE_3011	AFE_0246	8-amino-7-oxononanoate synthase, putative; Identified by match to protein family HMM PF00155; match to protein family HMM PF00202.	Dethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring.	0.876
AFE_3011	bioF	AFE_3011	AFE_0243	8-amino-7-oxononanoate synthase, putative; Identified by match to protein family HMM PF00155; match to protein family HMM PF00202.	8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.	0.919
amtB	AFE_1925	AFE_1922	AFE_1925	Identified by match to protein family HMM PF00909.	CBS domain protein; Identified by match to protein family HMM PF00571.	0.805
amtB	bioA	AFE_1922	AFE_1924	Identified by match to protein family HMM PF00909.	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Identified by similarity to SP:P53555; match to protein family HMM PF00202; match to protein family HMM TIGR00508; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.805
amtB	mutL	AFE_1922	AFE_1927	Identified by match to protein family HMM PF00909.	Mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.	0.779
amtB	nnrD	AFE_1922	AFE_1923	Identified by match to protein family HMM PF00909.	YjeF-related protein; Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S-and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.	0.773
bioA	AFE_1925	AFE_1924	AFE_1925	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Identified by similarity to SP:P53555; match to protein family HMM PF00202; match to protein family HMM TIGR00508; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	CBS domain protein; Identified by match to protein family HMM PF00571.	0.805
bioA	AFE_3011	AFE_1924	AFE_3011	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Identified by similarity to SP:P53555; match to protein family HMM PF00202; match to protein family HMM TIGR00508; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	8-amino-7-oxononanoate synthase, putative; Identified by match to protein family HMM PF00155; match to protein family HMM PF00202.	0.782
bioA	amtB	AFE_1924	AFE_1922	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Identified by similarity to SP:P53555; match to protein family HMM PF00202; match to protein family HMM TIGR00508; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Identified by match to protein family HMM PF00909.	0.805
bioA	bioB	AFE_1924	AFE_0259	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Identified by similarity to SP:P53555; match to protein family HMM PF00202; match to protein family HMM TIGR00508; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family.	0.991
bioA	bioD-1	AFE_1924	AFE_1675	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Identified by similarity to SP:P53555; match to protein family HMM PF00202; match to protein family HMM TIGR00508; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Dethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring.	0.998
bioA	bioD-2	AFE_1924	AFE_0246	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Identified by similarity to SP:P53555; match to protein family HMM PF00202; match to protein family HMM TIGR00508; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Dethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring.	0.998
bioA	bioF	AFE_1924	AFE_0243	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Identified by similarity to SP:P53555; match to protein family HMM PF00202; match to protein family HMM TIGR00508; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.	0.995