| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AFE_2061 | AFE_2062 | AFE_2061 | AFE_2062 | CBS domain protein; Identified by match to protein family HMM PF00571; match to protein family HMM PF01595; match to protein family HMM PF03471. | CBS domain protein; Identified by match to protein family HMM PF00571. | 0.746 |
| AFE_2061 | folC | AFE_2061 | AFE_2066 | CBS domain protein; Identified by match to protein family HMM PF00571; match to protein family HMM PF01595; match to protein family HMM PF03471. | Folylpolyglutamate synthase/dihydrofolate synthase; Identified by similarity to SP:P08192; match to protein family HMM PF02875; match to protein family HMM PF08245; match to protein family HMM TIGR01499; Belongs to the folylpolyglutamate synthase family. | 0.579 |
| AFE_2061 | queA | AFE_2061 | AFE_2060 | CBS domain protein; Identified by match to protein family HMM PF00571; match to protein family HMM PF01595; match to protein family HMM PF03471. | S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). | 0.805 |
| AFE_2061 | secD | AFE_2061 | AFE_2057 | CBS domain protein; Identified by match to protein family HMM PF00571; match to protein family HMM PF01595; match to protein family HMM PF03471. | Protein-export membrane protein SecD; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. | 0.674 |
| AFE_2061 | secF | AFE_2061 | AFE_2056 | CBS domain protein; Identified by match to protein family HMM PF00571; match to protein family HMM PF01595; match to protein family HMM PF03471. | Protein-export membrane protein SecF; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. | 0.676 |
| AFE_2061 | tgt | AFE_2061 | AFE_2059 | CBS domain protein; Identified by match to protein family HMM PF00571; match to protein family HMM PF01595; match to protein family HMM PF03471. | Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form th [...] | 0.806 |
| AFE_2061 | yajC | AFE_2061 | AFE_2058 | CBS domain protein; Identified by match to protein family HMM PF00571; match to protein family HMM PF01595; match to protein family HMM PF03471. | Preprotein translocase, YajC subunit; The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions. | 0.686 |
| AFE_2062 | AFE_2061 | AFE_2062 | AFE_2061 | CBS domain protein; Identified by match to protein family HMM PF00571. | CBS domain protein; Identified by match to protein family HMM PF00571; match to protein family HMM PF01595; match to protein family HMM PF03471. | 0.746 |
| AFE_2062 | folC | AFE_2062 | AFE_2066 | CBS domain protein; Identified by match to protein family HMM PF00571. | Folylpolyglutamate synthase/dihydrofolate synthase; Identified by similarity to SP:P08192; match to protein family HMM PF02875; match to protein family HMM PF08245; match to protein family HMM TIGR01499; Belongs to the folylpolyglutamate synthase family. | 0.590 |
| AFE_2062 | queA | AFE_2062 | AFE_2060 | CBS domain protein; Identified by match to protein family HMM PF00571. | S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). | 0.746 |
| AFE_2062 | secD | AFE_2062 | AFE_2057 | CBS domain protein; Identified by match to protein family HMM PF00571. | Protein-export membrane protein SecD; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. | 0.615 |
| AFE_2062 | secF | AFE_2062 | AFE_2056 | CBS domain protein; Identified by match to protein family HMM PF00571. | Protein-export membrane protein SecF; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. | 0.615 |
| AFE_2062 | tgt | AFE_2062 | AFE_2059 | CBS domain protein; Identified by match to protein family HMM PF00571. | Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form th [...] | 0.747 |
| AFE_2062 | yajC | AFE_2062 | AFE_2058 | CBS domain protein; Identified by match to protein family HMM PF00571. | Preprotein translocase, YajC subunit; The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions. | 0.624 |
| folC | AFE_2061 | AFE_2066 | AFE_2061 | Folylpolyglutamate synthase/dihydrofolate synthase; Identified by similarity to SP:P08192; match to protein family HMM PF02875; match to protein family HMM PF08245; match to protein family HMM TIGR01499; Belongs to the folylpolyglutamate synthase family. | CBS domain protein; Identified by match to protein family HMM PF00571; match to protein family HMM PF01595; match to protein family HMM PF03471. | 0.579 |
| folC | AFE_2062 | AFE_2066 | AFE_2062 | Folylpolyglutamate synthase/dihydrofolate synthase; Identified by similarity to SP:P08192; match to protein family HMM PF02875; match to protein family HMM PF08245; match to protein family HMM TIGR01499; Belongs to the folylpolyglutamate synthase family. | CBS domain protein; Identified by match to protein family HMM PF00571. | 0.590 |
| folC | queA | AFE_2066 | AFE_2060 | Folylpolyglutamate synthase/dihydrofolate synthase; Identified by similarity to SP:P08192; match to protein family HMM PF02875; match to protein family HMM PF08245; match to protein family HMM TIGR01499; Belongs to the folylpolyglutamate synthase family. | S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). | 0.591 |
| folC | secD | AFE_2066 | AFE_2057 | Folylpolyglutamate synthase/dihydrofolate synthase; Identified by similarity to SP:P08192; match to protein family HMM PF02875; match to protein family HMM PF08245; match to protein family HMM TIGR01499; Belongs to the folylpolyglutamate synthase family. | Protein-export membrane protein SecD; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. | 0.539 |
| folC | secF | AFE_2066 | AFE_2056 | Folylpolyglutamate synthase/dihydrofolate synthase; Identified by similarity to SP:P08192; match to protein family HMM PF02875; match to protein family HMM PF08245; match to protein family HMM TIGR01499; Belongs to the folylpolyglutamate synthase family. | Protein-export membrane protein SecF; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. | 0.539 |
| folC | tgt | AFE_2066 | AFE_2059 | Folylpolyglutamate synthase/dihydrofolate synthase; Identified by similarity to SP:P08192; match to protein family HMM PF02875; match to protein family HMM PF08245; match to protein family HMM TIGR01499; Belongs to the folylpolyglutamate synthase family. | Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form th [...] | 0.616 |
