| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AFE_2065 | accD | AFE_2065 | AFE_2067 | CvpA family protein; Identified by similarity to SP:P08550; match to protein family HMM PF02674. | acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. | 0.728 |
| AFE_2065 | folC | AFE_2065 | AFE_2066 | CvpA family protein; Identified by similarity to SP:P08550; match to protein family HMM PF02674. | Folylpolyglutamate synthase/dihydrofolate synthase; Identified by similarity to SP:P08192; match to protein family HMM PF02875; match to protein family HMM PF08245; match to protein family HMM TIGR01499; Belongs to the folylpolyglutamate synthase family. | 0.843 |
| AFE_2065 | metZ | AFE_2065 | AFE_2063 | CvpA family protein; Identified by similarity to SP:P08550; match to protein family HMM PF02674. | O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. | 0.799 |
| AFE_2065 | purF | AFE_2065 | AFE_2064 | CvpA family protein; Identified by similarity to SP:P08550; match to protein family HMM PF02674. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. | 0.982 |
| AFE_2065 | trpA | AFE_2065 | AFE_2068 | CvpA family protein; Identified by similarity to SP:P08550; match to protein family HMM PF02674. | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.723 |
| AFE_2065 | trpB | AFE_2065 | AFE_2069 | CvpA family protein; Identified by similarity to SP:P08550; match to protein family HMM PF02674. | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.723 |
| AFE_2065 | trpF | AFE_2065 | AFE_2070 | CvpA family protein; Identified by similarity to SP:P08550; match to protein family HMM PF02674. | N-(5'phosphoribosyl)anthranilate isomerase; Identified by similarity to SP:Q56320; match to protein family HMM PF00697; Belongs to the TrpF family. | 0.718 |
| AFE_2065 | truA | AFE_2065 | AFE_2071 | CvpA family protein; Identified by similarity to SP:P08550; match to protein family HMM PF02674. | tRNA pseudouridine synthase A; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. | 0.685 |
| accD | AFE_2065 | AFE_2067 | AFE_2065 | acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. | CvpA family protein; Identified by similarity to SP:P08550; match to protein family HMM PF02674. | 0.728 |
| accD | folC | AFE_2067 | AFE_2066 | acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. | Folylpolyglutamate synthase/dihydrofolate synthase; Identified by similarity to SP:P08192; match to protein family HMM PF02875; match to protein family HMM PF08245; match to protein family HMM TIGR01499; Belongs to the folylpolyglutamate synthase family. | 0.809 |
| accD | metZ | AFE_2067 | AFE_2063 | acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. | O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. | 0.729 |
| accD | purF | AFE_2067 | AFE_2064 | acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. | 0.776 |
| accD | trpA | AFE_2067 | AFE_2068 | acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.832 |
| accD | trpB | AFE_2067 | AFE_2069 | acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.826 |
| accD | trpF | AFE_2067 | AFE_2070 | acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. | N-(5'phosphoribosyl)anthranilate isomerase; Identified by similarity to SP:Q56320; match to protein family HMM PF00697; Belongs to the TrpF family. | 0.828 |
| accD | truA | AFE_2067 | AFE_2071 | acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. | tRNA pseudouridine synthase A; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. | 0.700 |
| folC | AFE_2065 | AFE_2066 | AFE_2065 | Folylpolyglutamate synthase/dihydrofolate synthase; Identified by similarity to SP:P08192; match to protein family HMM PF02875; match to protein family HMM PF08245; match to protein family HMM TIGR01499; Belongs to the folylpolyglutamate synthase family. | CvpA family protein; Identified by similarity to SP:P08550; match to protein family HMM PF02674. | 0.843 |
| folC | accD | AFE_2066 | AFE_2067 | Folylpolyglutamate synthase/dihydrofolate synthase; Identified by similarity to SP:P08192; match to protein family HMM PF02875; match to protein family HMM PF08245; match to protein family HMM TIGR01499; Belongs to the folylpolyglutamate synthase family. | acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. | 0.809 |
| folC | folP | AFE_2066 | AFE_2635 | Folylpolyglutamate synthase/dihydrofolate synthase; Identified by similarity to SP:P08192; match to protein family HMM PF02875; match to protein family HMM PF08245; match to protein family HMM TIGR01499; Belongs to the folylpolyglutamate synthase family. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.997 |
| folC | guaA | AFE_2066 | AFE_1778 | Folylpolyglutamate synthase/dihydrofolate synthase; Identified by similarity to SP:P08192; match to protein family HMM PF02875; match to protein family HMM PF08245; match to protein family HMM TIGR01499; Belongs to the folylpolyglutamate synthase family. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.664 |
