Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
nucEndonuclease; Identified by similarity to PIR:I79276. (213 aa)    
Predicted Functional Partners:
sppA
Signal peptide peptidase SppA, 67K type; Identified by similarity to SP:P08395; match to protein family HMM PF01343; match to protein family HMM TIGR00705; match to protein family HMM TIGR00706.
       0.542
proS
prolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves dea [...]
  
  
 0.471
AFE_1514
Conserved hypothetical protein; Identified by similarity to GB:BAC47013.1; match to protein family HMM PF03270; match to protein family HMM TIGR02935.
      
 0.461
AFE_2253
Conserved hypothetical protein; Identified by similarity to GB:BAB48985.1; match to protein family HMM PF00515; match to protein family HMM PF01835; match to protein family HMM PF07703.
   
    0.431
glgA
Glycogen synthase; Synthesizes alpha-1,4-glucan chains using ADP-glucose.
     
 0.430
AFE_0477
Virulence protein, putative; Identified by similarity to SP:Q05459; match to protein family HMM PF04014.
      
 0.420
AFE_2130
Virulence-associated protein, putative; Identified by similarity to SP:Q05459.
      
 0.420
AFE_2771
SpoVT/AbrB like domain protein.
      
 0.420
AFE_1551
Sucrose phosphate synthase; Identified by match to protein family HMM PF00534; match to protein family HMM PF05116; match to protein family HMM PF08282; match to protein family HMM TIGR01484; match to protein family HMM TIGR02471; match to protein family HMM TIGR02472.
  
 
 0.416
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
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