Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AFE_2123MTA/SAH nucleosidase, putative; Identified by similarity to SP:P24247; match to protein family HMM PF01048; match to protein family HMM TIGR03468. (237 aa)    
Predicted Functional Partners:
shc
Squalene-hopene cyclase; Identified by similarity to SP:P33990; match to protein family HMM PF00432; match to protein family HMM TIGR01507; match to protein family HMM TIGR01787.
 
   
 0.957
AFE_2122
Conserved hypothetical protein; Identified by match to protein family HMM PF00106; match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF04321; match to protein family HMM PF05368; match to protein family HMM PF07993; match to protein family HMM TIGR03466.
 
     0.943
AFE_2125
Identified by match to protein family HMM PF00494.
 
   
 0.939
ahcY
Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
    
 0.922
AFE_1826
Identified by match to protein family HMM PF01979; match to protein family HMM PF07969.
    
 0.910
AFE_1999
Autoinducer synthesis protein; Identified by similarity to SP:P12747; match to protein family HMM PF00765.
     
 0.904
AFE_2118
Membrane protein, putative; Identified by similarity to GB:CAD85670.1; match to protein family HMM TIGR03480.
 
     0.901
AFE_0150
Conserved hypothetical protein; Identified by similarity to GB:CAE33855.1.
     
  0.900
speE
Spermidine synthase; Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
     
  0.900
AFE_0432
Conserved hypothetical protein TIGR00726; Identified by similarity to GB:AAQ59864.1; match to protein family HMM PF02578; match to protein family HMM TIGR00726; Belongs to the multicopper oxidase YfiH/RL5 family.
    
  0.900
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
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