Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AFE_2131Aldehyde dehydrogenase (NAD) family protein; Identified by match to protein family HMM PF00171; Belongs to the aldehyde dehydrogenase family. (506 aa)    
Predicted Functional Partners:
AFE_0697
S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Identified by similarity to SP:P72324; match to protein family HMM PF00107; match to protein family HMM PF08240; match to protein family HMM TIGR02818; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.
  
 0.924
acs
acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.
   
 0.917
AFE_0846
Alcohol dehydrogenase, zinc-containing; Identified by similarity to SP:P75691; match to protein family HMM PF00107; match to protein family HMM PF08240.
  
 0.914
AFE_2088
Zinc-binding alcohol dehydrogenase family protein; Identified by match to protein family HMM PF08240; match to protein family HMM TIGR02822.
  
 0.914
ackA
Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family.
    
 0.911
AFE_1742
Aldehyde dehydrogenase (NAD) family protein; Identified by match to protein family HMM PF00171; Belongs to the aldehyde dehydrogenase family.
  
  
 
0.901
AFE_3010
Polyketide synthase, type I, putative; Identified by similarity to GB:AAK26474.1; match to protein family HMM PF00106; match to protein family HMM PF00107; match to protein family HMM PF00109; match to protein family HMM PF00550; match to protein family HMM PF00698; match to protein family HMM PF02801; match to protein family HMM PF08240; match to protein family HMM PF08659.
  
 
 0.768
fixX
Ferredoxin-like protein; Could be a 3Fe-4S cluster-containing protein.
      
 0.717
AFE_1743
Conserved hypothetical protein; Identified by similarity to PIR:H83734.
 
    0.690
pdhC
Pyruvate dehydrogenase complex, E2 and E3 components; Dihydrolipoamide acetyltransferase/dihydrolipoamide dehydrogenase; identified by similarity to PIR:C59237; match to protein family HMM PF00070; match to protein family HMM PF00198; match to protein family HMM PF00364; match to protein family HMM PF02817; match to protein family HMM PF02852; match to protein family HMM PF07992.
  
 0.666
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
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