Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AFE_2137Hydrolase, isochorismatase family; Identified by match to protein family HMM PF00857. (181 aa)    
Predicted Functional Partners:
pcm-1
protein-L-isoaspartate O-methyltransferase; Identified by similarity to SP:P24206; match to protein family HMM PF01135.
   
   0.813
AFE_2138
PDZ domain protein; Identified by match to protein family HMM PF05299.
       0.805
AFE_2135
Identified by match to protein family HMM PF02470.
       0.538
AFE_2134
Lipoprotein, putative; Identified by similarity to GB:CAD13844.1.
       0.523
nadE
Glutamine-dependent NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
  
 
 0.486
gpsA
Glycerol-3-phosphate dehydrogenase (NAD(P)+); Identified by similarity to SP:P37606; match to protein family HMM PF01210; match to protein family HMM PF07479; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
  
   0.478
draG
ADP-ribosyl-[dinitrogen reductase] hydrolase; Identified by match to protein family HMM PF03747; match to protein family HMM TIGR01616; match to protein family HMM TIGR02662; Belongs to the ArsC family.
 
  
 0.400
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.