Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AFE_2143Hypothetical protein; Identified by glimmer; putative. (85 aa)    
Predicted Functional Partners:
AFE_2142
Conserved hypothetical protein; Identified by similarity to GB:AAO28668.1; match to protein family HMM PF05164.
       0.732
AFE_2144
Penicillin-binding protein 2, putative; Identified by similarity to SP:P08150; match to protein family HMM PF00905; match to protein family HMM PF03717; match to protein family HMM TIGR03423.
       0.573
rplY
Ribosomal protein L25; This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
       0.555
pth
peptidyl-tRNA hydrolase; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Belongs to the PTH family.
       0.555
ychF
GTP-binding protein YchF; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
       0.548
AFE_2148
DNA-binding protein, putative; Identified by similarity to GB:AAO56394.1; match to protein family HMM PF01381; match to protein family HMM PF07883.
       0.421
hyfB
Hydrogenase-4, B subunit; Identified by similarity to SP:P23482; match to protein family HMM PF00361.
       0.421
hyfC
Hydrogenase-4, C subunit; Identified by similarity to SP:P77858; match to protein family HMM PF00146.
       0.421
hyfE
Hydrogenase-4, E subunit; Identified by similarity to SP:P77524.
       0.421
hyfF
Hydrogenase-4, F subunit; Identified by similarity to SP:P77437; match to protein family HMM PF00361.
       0.421
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
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