Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AFE_2144Penicillin-binding protein 2, putative; Identified by similarity to SP:P08150; match to protein family HMM PF00905; match to protein family HMM PF03717; match to protein family HMM TIGR03423. (636 aa)    
Predicted Functional Partners:
rodA
Rod shape-determining protein RodA; Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily.
 0.979
mrdA
Penicillin-binding protein 2; Catalyzes cross-linking of the peptidoglycan cell wall.
  
  
 
0.909
ftsW
Cell division protein FtsW; Identified by similarity to SP:P16457; match to protein family HMM PF01098; match to protein family HMM TIGR02614; Belongs to the SEDS family.
 
 0.896
mreC
Rod shape-determining protein MreC; Involved in formation and maintenance of cell shape.
 
 
 0.854
mreB
Rod shape-determining protein MreB; Identified by similarity to SP:P13519; match to protein family HMM PF06723; match to protein family HMM TIGR00904.
 
 
 
 0.833
ftsQ
Cell division protein FtsQ; Essential cell division protein; Belongs to the FtsQ/DivIB family. FtsQ subfamily.
  
 
 0.807
rplY
Ribosomal protein L25; This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
     
 0.787
pth
peptidyl-tRNA hydrolase; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Belongs to the PTH family.
  
    0.785
ychF
GTP-binding protein YchF; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
       0.773
ftsL
Cell division protein FtsL; Essential cell division protein; Belongs to the FtsL family.
  
 
 0.742
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
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