Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
AFE_2224Glycosyl hydrolase, family 15; Identified by match to protein family HMM PF00723; match to protein family HMM PF09137. (786 aa)    
Predicted Functional Partners:
cga
Glucan 1,4-alpha-glucosidase; Identified by match to protein family HMM PF00723; match to protein family HMM PF09137.
  
  
 
0.914
glgB
1,4-alpha-glucan branching enzyme; Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position; Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
  
 
 0.911
AFE_2840
Glycosyl hydrolase, family 57; Identified by match to protein family HMM PF03065; match to protein family HMM PF09095.
  
 
  0.910
AFE_0527
Glycogen/starch/alpha-glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.
   
 
 0.905
AFE_1799
Identified by match to protein family HMM PF00343; match to protein family HMM TIGR02094.
   
 
 0.905
AFE_2225
Glucose 1-dehydrogenase, putative; Identified by similarity to SP:P39482; match to protein family HMM PF00106; match to protein family HMM PF08659.
 
     0.824
AFE_2223
Penicillin-binding protein 1A, putative; Identified by similarity to SP:P31776; match to protein family HMM PF00905; match to protein family HMM PF00912.
 
     0.799
AFE_2019
Conserved domain protein.
  
     0.659
AFE_1547
Membrane protein, putative; Identified by match to protein family HMM PF07690.
  
     0.644
cysS
cysteinyl-tRNA synthetase; Identified by similarity to SP:P21888; match to protein family HMM PF01406; match to protein family HMM PF09190; match to protein family HMM PF09334; match to protein family HMM TIGR00435; Belongs to the class-I aminoacyl-tRNA synthetase family.
       0.568
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
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