Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AFE_2253Conserved hypothetical protein; Identified by similarity to GB:BAB48985.1; match to protein family HMM PF00515; match to protein family HMM PF01835; match to protein family HMM PF07703. (1569 aa)    
Predicted Functional Partners:
AFE_2254
Penicillin-binding protein 1C, putative; Identified by similarity to SP:P76577; match to protein family HMM PF00905; match to protein family HMM PF00912.
 
   
 0.959
AFE_2252
Tat (twin-arginine translocation) pathway signal sequence domain protein; Identified by match to protein family HMM TIGR01409.
       0.517
AFE_2161
Conserved hypothetical protein; Identified by similarity to GB:AAM36869.1.
  
     0.513
AFE_2994
Conserved hypothetical protein; Identified by similarity to GB:AAM36869.1.
  
     0.497
AFE_2993
Conserved hypothetical protein; Identified by similarity to GB:AAM36869.1.
  
     0.459
nuc
Endonuclease; Identified by similarity to PIR:I79276.
   
    0.431
AFE_1127
Identified by similarity to PIR:A83628; match to protein family HMM PF05014.
 
     0.426
nrdR
Transcriptional regulator, NrdR family; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family.
    
   0.410
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
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