Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AFE_2299MotA/TolQ/ExbB proton channel family protein; Identified by match to protein family HMM PF01618. (225 aa)    
Predicted Functional Partners:
AFE_2300
Biopolymer transport protein, ExbD/TolR family; Identified by match to protein family HMM PF02472.
 
   0.958
AFE_3004
Biopolymer transport protein, ExbD/TolR family; Identified by match to protein family HMM PF02472.
  
   0.863
AFE_2269
Biopolymer transport protein, ExbD/TolR family; Identified by match to protein family HMM PF02472.
  
   0.861
AFE_0486
Biopolymer transport protein, ExbD/TolR family; Identified by match to protein family HMM PF02472.
  
   0.860
AFE_0769
Biopolymer transport protein, ExbD/TolR family; Identified by match to protein family HMM PF02472.
  
   0.860
AFE_1486
Biopolymer transport protein, ExbD/TolR family; Identified by match to protein family HMM PF02472.
  
   0.858
AFE_2301
TonB family protein; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. Belongs to the TonB family.
  
   0.810
AFE_2304
Identified by match to protein family HMM TIGR01352.
 
   0.718
AFE_2298
TonB-dependent receptor; Identified by match to protein family HMM PF00593; match to protein family HMM PF07715.
 
   
 0.696
AFE_3026
ABC transporter, ATP-binding protein; Identified by match to protein family HMM PF00005.
  
     0.696
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
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