Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AFE_2301TonB family protein; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. Belongs to the TonB family. (242 aa)    
Predicted Functional Partners:
AFE_2300
Biopolymer transport protein, ExbD/TolR family; Identified by match to protein family HMM PF02472.
  
   0.873
AFE_2299
MotA/TolQ/ExbB proton channel family protein; Identified by match to protein family HMM PF01618.
  
   0.810
AFE_2302
TonB-dependent receptor; Identified by match to protein family HMM PF00593; match to protein family HMM PF07715.
  
   0.803
AFE_2298
TonB-dependent receptor; Identified by match to protein family HMM PF00593; match to protein family HMM PF07715.
   
 
 0.619
AFE_2303
Conserved hypothetical protein; Identified by similarity to PIR:AG1979.
  
    0.590
AFE_2304
Identified by match to protein family HMM TIGR01352.
 
    
0.558
tolR
TolR protein; Identified by similarity to SP:P05829; match to protein family HMM PF02472; match to protein family HMM TIGR02801.
   
   0.464
AFE_0486
Biopolymer transport protein, ExbD/TolR family; Identified by match to protein family HMM PF02472.
   
   0.464
AFE_0769
Biopolymer transport protein, ExbD/TolR family; Identified by match to protein family HMM PF02472.
   
   0.464
AFE_2269
Biopolymer transport protein, ExbD/TolR family; Identified by match to protein family HMM PF02472.
   
   0.464
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
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