Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AFE_2365Conserved hypothetical protein; Identified by similarity to GB:AAN56110.1. (73 aa)    
Predicted Functional Partners:
AFE_2366
Transporter, AcrB/AcrD/AcrF family; Identified by match to protein family HMM PF00873; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
 
     0.924
AFE_2368
Outer membrane efflux protein; Identified by match to protein family HMM PF02321.
 
     0.863
AFE_2367
Efflux transporter, RND family, MFP subunit; Identified by match to protein family HMM TIGR01730; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
 
     0.853
AFE_2364
Rhodanese-like domain protein; Identified by match to protein family HMM PF00581.
  
  
 0.837
grxC
Glutaredoxin 3; Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.
  
    0.826
AFE_2362
Thioredoxin; Identified by match to protein family HMM PF00085; match to protein family HMM TIGR01068.
       0.695
AFE_2369
Transcriptional regulator, ArsR family; Identified by match to protein family HMM PF01022.
 
    0.558
AFE_1792
Sulfide-quinone reductase, putative; Catalyzes the oxidation of hydrogen sulfide, with the help of a quinone. Consecutive reaction cycles lead to the accumulation of a polysulfide product on the active site Cys residues; these products are released when they exceed a critical length, typically as cyclooctasulfur; Belongs to the SQRD family.
 
     0.499
AFE_2361
N-acetylmuramoyl-L-alanine amidase, putative; Identified by similarity to SP:Q46929; match to protein family HMM PF01476; match to protein family HMM PF01520; match to protein family HMM TIGR01409.
       0.486
rpS17
Ribosomal protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
   
   0.407
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
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