Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AFE_2386Identified by match to protein family HMM PF00899. (248 aa)    
Predicted Functional Partners:
AFE_2387
Hydrolase, TatD family; Identified by match to protein family HMM PF01026.
       0.805
AFE_2385
SCP-2 sterol transfer family protein; Identified by match to protein family HMM PF02036.
       0.614
AFE_2384
Conserved hypothetical protein; Identified by similarity to PIR:A82245.
       0.584
ubiD
3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Identified by similarity to SP:P26615; match to protein family HMM PF01977; match to protein family HMM TIGR00148; Belongs to the UbiD family.
       0.533
thiG
Thiamin biosynthesis protein ThiG; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
 
  
 0.532
ubiH-2
2-octaprenyl-6-methoxyphenol hydroxylase; Identified by similarity to SP:P25534; match to protein family HMM PF01494; match to protein family HMM TIGR01988.
       0.508
ubiH-1
2-octaprenyl-6-methoxyphenol hydroxylase; Identified by similarity to SP:P25534; match to protein family HMM PF01266; match to protein family HMM PF01494; match to protein family HMM TIGR01988.
       0.508
AFE_2390
Conserved hypothetical protein; Identified by similarity to GB:AAQ61663.1.
       0.496
moeB
Molybdopterin biosynthesis MoeB protein; Identified by similarity to SP:P12282; match to protein family HMM PF00899; match to protein family HMM PF05237.
 
 
0.469
cysM
Cysteine synthase B; Identified by similarity to SP:P16703; match to protein family HMM PF00291; match to protein family HMM TIGR01136; match to protein family HMM TIGR01138; Belongs to the cysteine synthase/cystathionine beta- synthase family.
   
 
 0.413
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
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