Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AFE_2449Conserved hypothetical protein; Identified by similarity to PIR:B75601; match to protein family HMM PF00462; match to protein family HMM PF05768. (79 aa)    
Predicted Functional Partners:
AFE_2448
Heavy metal-binding protein, putative; Identified by match to protein family HMM PF00403.
 
     0.871
nrdA
Ribonucleotide-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
  
 0.842
AFE_1547
Membrane protein, putative; Identified by match to protein family HMM PF07690.
  
     0.625
msrA
Peptide-methionine (S)-S-oxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
  
 
 0.625
AFE_2019
Conserved domain protein.
  
     0.624
AFE_2447
Conserved hypothetical protein; Identified by similarity to GB:AAO07819.1; match to protein family HMM PF03625.
       0.591
AFE_2021
Copper-translocating P-type ATPase; Identified by match to protein family HMM PF00122; match to protein family HMM PF00403; match to protein family HMM PF00702; match to protein family HMM TIGR01494; match to protein family HMM TIGR01511; match to protein family HMM TIGR01525.
  
 
 0.541
AFE_2947
Thiol:disulfide interchange protein DsbG, putative; Identified by similarity to SP:P77202.
 
     0.505
AFE_1862
Heavy metal-binding protein, putative; Identified by match to protein family HMM PF00403.
 
     0.500
AFE_3062
Conserved hypothetical protein; Identified by similarity to GB:BAC60875.1; match to protein family HMM PF02622; Belongs to the UPF0301 (AlgH) family.
     
  0.500
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
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