Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AFE_2546Radical SAM domain protein; Identified by match to protein family HMM PF04055. (377 aa)    
Predicted Functional Partners:
AFE_2543
Radical SAM domain protein; Identified by match to protein family HMM PF04055.
 
  
  0.990
AFE_2544
Identified by match to protein family HMM PF01494; match to protein family HMM PF05834; match to protein family HMM TIGR02032.
 
     0.913
AFE_2545
Lipoate-protein ligase A, putative; Identified by similarity to PIR:C70441; match to protein family HMM PF03099.
 
     0.913
lipB
Lipoate-protein ligase B; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
     
  0.900
lipA
Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
     
  0.900
AFE_2549
Glycine cleavage system protein H, putative; Identified by similarity to SP:P23884; match to protein family HMM PF01597.
 
   
 0.878
AFE_2548
Conserved hypothetical protein; Identified by similarity to PIR:A83048.
 
     0.877
AFE_2553
Pyridine nucleotide-disulfide oxidoreductase; Identified by similarity to PIR:G70335; match to protein family HMM PF00070; match to protein family HMM PF07992.
 
     0.861
AFE_2552
Conserved hypothetical protein; Identified by similarity to PIR:H70335.
 
     0.858
AFE_2551
Iron-sulfur cluster-binding protein.
 
     0.854
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
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