Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AFE_2600Conserved hypothetical protein; Identified by similarity to SP:O29695; match to protein family HMM PF01206; Belongs to the sulfur carrier protein TusA family. (76 aa)    
Predicted Functional Partners:
AFE_2599
Conserved hypothetical protein; Identified by similarity to PIR:C69319.
 
  
 0.966
AFE_2601
Pyridine nucleotide-disulfide oxidoreductase; Identified by similarity to SP:Q9R112; match to protein family HMM PF07992.
 
   
 0.812
AFE_1839
Conserved hypothetical protein; Identified by similarity to PIR:C82434.
   
  
 0.726
AFE_2018
Conserved hypothetical protein; Identified by similarity to PIR:C70988.
      
 0.724
AFE_3116
Conserved hypothetical protein; Identified by similarity to PIR:C69319.
 
  
 0.702
AFE_2557
Conserved hypothetical protein; Identified by similarity to GB:CAD85318.1; match to protein family HMM PF01206; Belongs to the sulfur carrier protein TusA family.
  
     0.700
iscS-3
Cysteine desulfurase IscS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
   
 
 0.560
iscS-2
Cysteine desulfurase; Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine.
   
 
 0.560
iscS-1
Cysteine desulfurase; Identified by similarity to SP:O54055; match to protein family HMM PF00266.
   
 
 0.560
AFE_3118
Pyridine nucleotide-disulfide oxidoreductase; Identified by similarity to SP:Q9R112; match to protein family HMM PF07992.
 
   
 0.509
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
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