Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
fumCFumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (457 aa)    
Predicted Functional Partners:
citZ
Citrate synthase II; Identified by similarity to SP:P39120; match to protein family HMM PF00285; match to protein family HMM TIGR01800; Belongs to the citrate synthase family.
   
 0.992
AFE_3000
Identified by similarity to SP:Q60176; match to protein family HMM PF00056.
  
 0.987
AFE_0660
Malic enzyme family protein; Identified by similarity to SP:O30808; match to protein family HMM PF00390; match to protein family HMM PF03949.
  
 
 0.970
AFE_0423
Aconitate hydratase, putative; Identified by match to protein family HMM PF00330; match to protein family HMM PF00694; match to protein family HMM TIGR01342.
  
 0.967
AFE_1546
Succinate-semialdehyde dehydrogenase, putative; Identified by similarity to SP:P25526; match to protein family HMM PF00171.
   
 0.899
atpA
ATP synthase F1, alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family.
   
 0.863
pdhC
Pyruvate dehydrogenase complex, E2 and E3 components; Dihydrolipoamide acetyltransferase/dihydrolipoamide dehydrogenase; identified by similarity to PIR:C59237; match to protein family HMM PF00070; match to protein family HMM PF00198; match to protein family HMM PF00364; match to protein family HMM PF02817; match to protein family HMM PF02852; match to protein family HMM PF07992.
   
 0.847
nadB
L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate.
      0.841
argH
Argininosuccinate lyase; Identified by similarity to SP:O34858; match to protein family HMM PF00206; match to protein family HMM TIGR00838.
   
 
 0.832
AFE_1472
Identified by match to protein family HMM PF01557.
   
  0.823
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
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